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Article

Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice

19 Aug 2022

Abstract excerpt

Abstract The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients. Here, we map the transcriptional profiles of 144 responding and non-responding tumours within two mouse models at four time points during...

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PMID: 35986006
DOI: 10.1038/s41467-022-32567-8

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