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Article

Clonal hematopoiesis associated with epigenetic aging and clinical outcomes

29 May 2021

Abstract excerpt

Abstract Clonal hematopoiesis of indeterminate potential (CHIP) is a common precursor state for blood cancers that most frequently occurs due to mutations in the DNA‐methylation modifying enzymes DNMT3A or TET2. We used DNA‐methylation array and whole‐genome sequencing data from four cohorts together comprising 5522 persons to study the association between CHIP, epigenetic clocks, and health outcomes. CHIP was...

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PMID: 34050697
DOI: 10.1111/acel.13366

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