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Article

Single-cell transcriptome analyses reveal distinct gene expression signatures of severe COVID-19 in the presence of clonal hematopoiesis.

Experimental & molecular medicine - 1 Oct 2022

Choi Baekgyu, Kang Chang Kyung, Park Seongwan, Lee Dohoon, Lee Andrew J, Ko Yuji, Kang Suk-Jo, Kang Kyuho, Kim Sun, Koh Youngil, Jung Inkyung

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP), a common aging-related process that predisposes individuals to various inflammatory responses, has been reported to be associated with COVID-19 severity. However, the immunological signature and the exact gene expression program by which the presence of CHIP exerts its clinical impact on COVID-19 remain to be elucidated. In this study, we generated a...

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Chromatin
Clonal Hematopoiesis
COVID-19
Gene Expression Profiling
Hematopoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

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PMID: 36229591
DOI: 10.1038/s12276-022-00866-1
PMCID: PMC9559247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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