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Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease

12 Sept 2022

Abstract excerpt

Age-related changes to the genome-wide DNA methylation (DNAm) pattern observed in blood are well-documented. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-related acquisition and expansion of leukemogenic mutations in hematopoietic stem cells (HSCs), is associated with blood cancer and coronary artery disease (CAD). Epigenetic regulators DNMT3A and TET2 are the two most...

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PMID: 36097025
DOI: 10.1038/s41467-022-33093-3

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