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Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation

20 May 2025

Abstract excerpt

With age, hematopoietic stem cells can acquire somatic mutations in leukemogenic genes that confer a proliferative advantage in a phenomenon termed CHIP. How these mutations result in increased risk for numerous age-related diseases remains poorly understood. We conduct a multiracial meta-analysis of EWAS of CHIP in the Framingham Heart Study, Jackson Heart Study, Cardiovascular Health Study, and Atherosclerosis...

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PMID: 40393957
DOI: 10.1038/s41467-025-59333-w

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