Article

Stem cell differentiation is a stochastic process with memory

2017-01-17

Abstract excerpt

Pluripotent stem cells are able to self-renew indefinitely in culture and differentiate into all somatic cell types in vivo . While much is known about the molecular basis of pluripotency, the molecular mechanisms of lineage commitment are complex and only partially understood. Here, using a combination of single cell profiling and mathematical modeling, we examine the differentiation dynamics of individual mouse...

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Literature Corpus work: c256fbe1-bd14-544e-9f87-bcba4fe0bed2
DOI: 10.1101/101048

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