Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells.

doi:10.1038/nature13458

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Article

Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells.

Nature - 4 Sept 2014

Shipony Zohar, Mukamel Zohar, Cohen Netta Mendelson, Landan Gilad, Chomsky Elad, Zeliger Shlomit Reich, Fried Yael Chagit, Ainbinder Elena, Friedman Nir, Tanay Amos

Abstract excerpt

Stable maintenance of gene regulatory programs is essential for normal function in multicellular organisms. Epigenetic mechanisms, and DNA methylation in particular, are hypothesized to facilitate such maintenance by creating cellular memory that can be written during embryonic development and then guide cell-type-specific gene expression. Here we develop new methods for quantitative inference of DNA methylation...

Topics

Alleles
Cell Line
Cell Line, Tumor
Clone Cells
DNA Methylation
Embryonic Stem Cells
Epigenesis, Genetic
Fibroblasts
Genome, Human
Humans
Induced Pluripotent Stem Cells

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Open in PubMed

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PMID: 25043040
DOI: 10.1038/nature13458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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