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Moxifloxacin-mediated killing of <i>Mycobacterium tuberculosis</i> involves respiratory downshift, reductive stress, and ROS accumulation

2022-04-04

Abstract excerpt

Moxifloxacin is central to treatment of multidrug-resistant tuberculosis. Effects of moxifloxacin on Mycobacterium tuberculosis redox state were explored to identify strategies for increasing lethality and reducing the prevalence of extensively resistant tuberculosis. A non-invasive redox biosensor and an ROS-sensitive dye revealed that moxifloxacin induces oxidative stress correlated with M. tuberculosis death....

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Literature Corpus work
c24371e7-db63-5b70-911c-c1add9f812e6
DOI
10.1101/2022.04.04.486929
Open publication

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