Article

A new stress-response pathway in <i>Mycobacterium tuberculosis</i>

2026-04-16

Abstract excerpt

Metabolic adaptations are key in the virulence of the pathogen Mycobacterium tuberculosis (Mtb). However, our current understanding of these adaptations is limited to common pathways in central carbon metabolism. Here we apply an untargeted bottom-up approach to discover unknown stress-responsive metabolites and their biosynthetic enzyme. We show that upon exposure to hypoxia, nitric oxide and activated macrophag...

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Literature Corpus work: f339c8d8-635e-5c63-8963-21f840bc3375
DOI: 10.64898/2026.04.15.718621

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