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Uncovering the Roles of <i>Mycobacterium tuberculosis melH</i> in Redox and Bioenergetic Homeostasis: Implications for Antitubercular Therapy

2023-10-03

Abstract excerpt

Mycobacterium tuberculosis ( Mtb ), the pathogenic bacterium that causes tuberculosis, has evolved sophisticated defense mechanisms to counteract the cytotoxicity of reactive oxygen species (ROS) generated within host macrophages during infection. The melH gene in Mtb and Mycobacterium marinum ( Mm ) plays a crucial role in defense mechanisms against ROS generated during infection. We demonstrate that melH e...

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Literature Corpus work
778f07d8-c8fd-59c2-b118-976c53fb46d7
DOI
10.1101/2023.10.02.560593
Open publication

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