Article

Myoglobin Inhibits Breast Cancer Cell Fatty Acid Oxidation and Migration via Heme-dependent Oxidant Production and Not Fatty Acid Binding

2024-05-03

Abstract excerpt

The monomeric heme protein myoglobin (Mb), traditionally thought to be expressed exclusively in cardiac and skeletal muscle, is now known to be expressed in approximately 40% of breast tumors. While Mb expression is associated with better patient prognosis, the molecular mechanisms by which Mb limits cancer progression are unclear. In muscle, Mb’s predominant function is oxygen storage and delivery, which is depen...

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Literature Corpus work: c22981a6-0bf1-5ff1-a49c-e2c6dc30e1b2
DOI: 10.1101/2024.04.30.591659

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