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Article

The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α

4 Apr 2016

Abstract excerpt

Triple‐negative breast cancer (TNBC) represents the most aggressive breast tumor subtype. However, the molecular determinants responsible for the metastatic TNBC phenotype are only partially understood. We here show that expression of the mitochondrial calcium uniporter (MCU), the selective channel responsible for mitochondrial Ca2+ uptake, correlates with tumor size and lymph node infiltration, suggesting that...

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PMID: 27138568
DOI: 10.15252/emmm.201606255

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