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Article

Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice.

American journal of physiology. Endocrinology and metabolism - 1 Jul 2021

Ono-Moore Kikumi D, Olfert I Mark, Rutkowsky Jennifer M, Chintapalli Sree V, Willis Brandon J, Blackburn Michael L, Williams D Keith, O'Reilly Juliana, Tolentino Todd, Lloyd K C Kent, Adams Sean H

Abstract excerpt

Myoglobin (Mb) is a regulator of O2 bioavailability in type I muscle and heart, at least when tissue O2 levels drop. Mb also plays a role in regulating cellular nitric oxide (NO) pools. Robust binding of long-chain fatty acids and long-chain acylcarnitines to Mb, and enhanced glucose metabolism in hearts of Mb knockout (KO) mice, suggest additional roles in muscle intermediary metabolism and fuel selection. To...

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Identifiers

PMID: 33969704
DOI: 10.1152/ajpendo.00624.2020
PMCID: PMC8321820

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