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Article

Targeting of MCL-1 in breast cancer-associated fibroblasts reverses their myofibroblastic phenotype and pro-invasive properties.

Cell death & disease - 14 Sept 2022

Bonneaud Thomas L, Lefebvre Chloé C, Nocquet Lisa, Basseville Agnes, Roul Julie, Weber Hugo, Campone Mario, Juin Philippe P, Souazé Frédérique

Abstract excerpt

Cancer-associated fibroblasts (CAF) are a major cellular component of epithelial tumors. In breast cancers in particular these stromal cells have numerous tumorigenic effects in part due to their acquisition of a myofibroblastic phenotype. Breast CAFs (bCAFs) typically express MCL-1. We show here that pharmacological inhibition or knock down of this regulator of mitochondrial integrity in primary bCAFs directly...

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Identifiers

PMID: 36104324
DOI: 10.1038/s41419-022-05214-9
PMCID: PMC9474880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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