Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis.

Abstract excerpt

As a tumor grows, it requires increased amounts of oxygen. However, the tumor blood vessels that form to meet this demand are functionally impaired, leading to regions of hypoxia within the tumor. Such hypoxia is one of the hallmarks of malignancy and is thought to promote a number of tumorigenic properties. Here, we sought to determine how tumors without hypoxia would progress by engineering A549 human lung...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Hypoxia
• Share to Hypoxia-Inducible Factor 1, alpha Subunit