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Article

Skeletal muscle reprogramming by breast cancer regardless of treatment history or tumor molecular subtype

4 Jun 2020

Abstract excerpt

Increased susceptibility to fatigue is a negative predictor of survival commonly experienced by women with breast cancer (BC). Here, we sought to identify molecular changes induced in human skeletal muscle by BC regardless of treatment history or tumor molecular subtype using RNA-sequencing (RNA-seq) and proteomic analyses. Mitochondrial dysfunction was apparent across all molecular subtypes, with the greatest...

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PMID: 32550263
DOI: 10.1038/s41523-020-0162-2

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