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Article

Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis

10 Jun 2014

Abstract excerpt

Memo is an evolutionarily conserved protein with a critical role in cell motility. We found that Memo was required for migration and invasion of breast cancer cells in vitro and spontaneous lung metastasis from breast cancer cell xenografts in vivo. Biochemical assays revealed that Memo is a copper-dependent redox enzyme that promoted a more oxidized intracellular milieu and stimulated the production of reactive...

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PMID: 24917593
DOI: 10.1126/scisignal.2004870

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