Article

Deciphering context-dependent epigenetic program by network-based prediction of clustered open regulatory elements from single-cell chromatin accessibility

2026-03-18

Abstract excerpt

Large cis-regulatory domains, spanning tens to hundreds of kilobases, are pivotal in orchestrating cell-state-specific transcriptional programs that define cellular identity. However, existing single-cell analytical frameworks lack the capacity to identify these higher-order structures, thereby obscuring the coordinated, domain-level epigenetic regulation essential for complex biological processes. To address this...

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Literature Corpus work: c1d466dc-7b9e-55ba-b3de-3654b493ad2c
DOI: 10.64898/2026.03.17.712366

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