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Computational Evaluation of B-Cell Clone Sizes in Bulk Populations

29 Jun 2018

Abstract excerpt

B cell clones expand and contract during adaptive immune responses and can persist or grow uncontrollably in lymphoproliferative disorders. One way to monitor and track B cell clones is to perform large-scale sampling of bulk cell populations, amplifying, and sequencing antibody gene rearrangements by next-generation sequencing (NGS). Here, we describe a series of computational approaches for estimating B cell...

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PMID: 30008715
DOI: 10.3389/fimmu.2018.01472

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