Article

MicroRNAs are required within a critical time window to define neural patterning during early human brain development

2026-04-01

Abstract excerpt

MicroRNAs (miRNAs) are key post-transcriptional regulators of cell state transitions, yet their function in early human brain development is largely unknown. Here, we present a longitudinal analysis of miRNA function in developing human forebrain organoids. We show that mRNAs and miRNAs expression mirrors known developmental gene programs and that miRNA biogenesis peaks at neural commitment. To test the function o...

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Literature Corpus work: c1d13f5c-1092-5191-8a39-3177b9e138d8
DOI: 10.64898/2026.03.30.715268

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