Article

Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain development

2025-05-21

Abstract excerpt

<h4>SUMMARY</h4> The early patterning of the anterior neuroectoderm constitutes a fundamental blueprint for human brain development, orchestrated by multiple signaling pathways. Among them, Sonic Hedgehog (SHH) plays a key influence. However, the transcriptional programs it engages remain poorly defined due to the limited accessibility of human brain tissue. To address this, we established a human induced pluripo...

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Literature Corpus work: 60250087-d988-5b93-94d2-4ec3ba3756f5
DOI: 10.1101/2025.05.20.654466

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