Article

U1 snRNP-Specific U1C Acts as the Gatekeeper of the Survival of Motor Neurons (SMN) Complex in snRNP Biogenesis

2024-11-11

Abstract excerpt

<h4>SUMMARY</h4> The stability and abundance of spliceosomal snRNPs are determined by the assembly of an Sm protein ring (Sm core) on each snRNA, a process facilitated by the survival of motor neuron (SMN) complex. Whereas the SMN complex’s role as a chaperone is well-established, the mechanisms that regulate its activity remain unclear. Our study identifies U1C, a U1 snRNP-specific protein, as a key regulator of...

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Literature Corpus work: ed72b8ee-2a31-5a4a-ba55-449efa6a92d3
DOI: 10.1101/2024.11.11.623077

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