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A CRISPRi Library Screen in Group B <i>Streptococcus</i> Identifies Surface Immunogenic Protein (Sip) as a Mediator of Multiple Host Interactions

2024-12-07

Abstract excerpt

Group B Streptococcus (GBS; Streptococcus agalactiae ) is an important pathobiont capable of colonizing various host environments, contributing to severe perinatal infections. Surface proteins play critical roles in GBS-host interactions, yet comprehensive studies of these proteins’ functions have been limited by genetic manipulation challenges. This study leveraged a CRISPR interference (CRISPRi) library to tar...

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Identifiers and source

Literature Corpus work
72000cb3-7d72-5fe3-8f95-c9dbf0f6536e
DOI
10.1101/2024.12.06.627252
Open publication

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A CRISPRi Library Screen in Group B <i>Streptococcus</i> Identifies Surface Immunogenic Protein (Sip) as a Mediator of Multiple Host InteractionsDOI 10.1101/2024.12.06.627252
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