Article

Blocking effect of Guan-Fu Base A on human Na V 1.5 channels and the mutants expressed in Xenopus Laevis oocytes

2022-07-13

Abstract excerpt

<h4>Introduction: </h4> GFA (Guan-Fu Base A) as one of the main active substances in the Chinese medicine Ranunculaceae Aconite, has been approved the effect of anti-atrial fibrillation via its atrial-selective Na + channel-blocking action. It is recently undergoing phase IV clinical study. However, the molecular mechanism of Na V 1.5 channel inhibition by GFA is largely unclear. <h4>Methods and Results: </h4>...

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Literature Corpus work: c1ca23b4-5534-5ee2-9b2f-69581a13a638
DOI: 10.22541/au.165772664.44721337/v1

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