Article

Increased early sodium current causes familial atrial fibrillation and dampens effect of flecainide

2022-01-20

Abstract excerpt

(1) <h4>Aims</h4> Atrial fibrillation (AF) is the most common cardiac arrhythmia. Pathogenic variants in genes encoding ion channels are associated with familial AF. The point mutation M1875T in the SCN5A gene, which encodes the α-subunit of the cardiac sodium channel Na v 1.5, has been associated with increased atrial excitability and familial AF. (2) <h4>Methods</h4> We designed a new murine model carrying...

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Literature Corpus work: 23d3df78-3394-5a2b-99b9-0b1036ec740b
DOI: 10.1101/2022.01.18.476646

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