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Na V 1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8a N1768D/+ gain-of-function mice

2023-08-06

Abstract excerpt

Inhibitors of voltage-gated sodium channels (Na V s) are important anti-epileptic drugs, but the contribution of specific channel isoforms is unknown since available inhibitors are nonselective. We created a series of compounds with diverse selectivity profiles enabling block of Na V 1.6 alone or together with Na V 1.2. Mice with a heterozygous gain-of-function mutation (N1768D/+) in Scn8a (encoding Na V 1.6)...

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Literature Corpus work: d2927167-174f-528a-89d0-5ca5b185411a
DOI: 10.1101/2023.08.03.551823

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Na <sub>V</sub> 1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and <i> Scn8a <sup>N1768D/+</sup> </i> gain-of-function mice

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