Article

More Severe Loss-of-Function Sodium Channel induced by Compound SCN5A R965C and R1309H Mutants lead to Complex Familial Arrhythmia Syndrome

2019-08-05

Abstract excerpt

<h4>[Abstract]</h4> <h4>Objective</h4> A complex familial arrhythmia syndrome was identified in a Chinese Han family, characterized by sick sinus syndrome, progressive conduction block, atrial fibrillation, atrial standstill and Brugada syndrome. The underlying mechanism associated with the genetic mutation was investigated. <h4>Methods</h4> Genetic analysis was conducted for probands in the coding and splicing...

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Literature Corpus work: 79f443ce-0592-53a4-9436-71fb3ddfc85f
DOI: 10.1101/725945

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