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Article

Electrophysiological and trafficking defects of the SCN5A T353I mutation in Brugada syndrome are rescued by alpha-allocryptopine.

European journal of pharmacology - 5 Jan 2015

Zhang Jiancheng, Chen Yu, Yang Jie, Xu Bin, Wen Yi, Xiang Guojian, Wei Guoliang, Zhu Chao, Xing Yanwei, Li Yang

Abstract excerpt

Brugada syndrome (BrS), which causes arrhythmias that lead to sudden cardiac death, is linked to loss-of-function mutations that affect sodium channels. Here, we investigate the rescue effect of alpha-allocryptopine (All) from Chinese herbal medicine in a T353I mutation of SCN5A, which combines trafficking abnormalities with Brugada syndrome. SCN5A-T353I expressed in HEK293 cells showed a small peak current...

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Identifiers

PMID: 25261036
DOI: 10.1016/j.ejphar.2014.09.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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