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Article

18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels.

Acta pharmacologica Sinica - 1 Jun 2012

Du Yi-mei, Xia Cheng-kun, Zhao Ning, Dong Qian, Lei Ming, Xia Jia-hong

Abstract excerpt

AIM: To compare the effects of two stereoisomeric forms of glycyrrhetinic acid on different components of Na(+) current, HERG and Kv1.5 channel currents. METHODS: Wild-type (WT) and long QT syndrome type 3 (LQT-3) mutant ΔKPQ Nav1.5 channels, as well as HERG and Kv1.5 channels were expressed in Xenopus oocytes. In addition, isolated human atrial myocytes were used. Two-microelectrode voltage-clamp technique was...

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Identifiers

PMID: 22609834
DOI: 10.1038/aps.2012.22
PMCID: PMC4010371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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