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Hydroxychloroquine Protects Against Cyclophosphamide-Induced Premature ovarian failure by Reducing Granulosa Cell Senescence via Regulation of the mtDNA-cGAS Signaling Pathway

2025-11-25

Abstract excerpt

<title>Abstract</title> <p>Cyclophosphamide (CTX) is widely used as a first-line chemotherapeutic agent for various cancers, but it is associated with significant risks of ovarian dysfunction, even progressing to premature ovarian failure (POF), with granulosa cell senescence being a key phenotypic manifestation. hydroxychloroquine (HCQ) has demonstrated anti-senescence properties in the context of age-related di...

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Literature Corpus work: c1c4d642-baad-57ef-a335-64881add8f00
DOI: 10.21203/rs.3.rs-8052573/v1

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Hydroxychloroquine Protects Against Cyclophosphamide-Induced Premature ovarian failure by Reducing Granulosa Cell Senescence via Regulation of the mtDNA-cGAS Signaling PathwayDOI 10.21203/rs.3.rs-8052573/v1Read

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