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The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency

6 Dec 2023

Abstract excerpt

Young female cancer patients can develop chemotherapy-induced primary ovarian insufficiency (POI). Cyclophosphamide (Cy) is one of the most widely used chemotherapies and has the highest risk of damaging the ovaries. Recent studies elucidated the pivotal roles of cellular senescence, which is characterized by permanent cell growth arrest, in the pathologies of various diseases. Moreover, several promising...

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PMID: 38139022
DOI: 10.3390/ijms242417193

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