Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ovarian aging‐associated downregulation of GPX4 expression regulates ovarian follicular development by affecting granulosa cell functions and oocyte quality

18 Mar 2025

Abstract excerpt

In the physiological state, female fertility declines with age, as evidenced by a steady decline in oocyte quantity and quality. Aging of the first organ, the ovary, is accompanied by increased oxidative stress levels in the ovary, causing a decline in the ovarian reserve and follicular atresia. Ferroptosis is a novel mode of programmed cell death discovered in recent years and is involved in the onset and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Epigenetics and DNA Methylation
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40100097
DOI: 10.1096/fj.202401580rr

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ovarian aging‐associated downregulation of GPX4 expression regulates ovarian follicular development by affecting granulosa cell functions and oocyte qualityPMID 40100097Read ↗

Thioredoxin-1 inhibits granulosa cell ferroptosis to rescue ovarian aging through mitophagy-dependent activation of BNIP3LSemantic proximity Read ↗

Ovarian Aging: Molecular Mechanisms and Medical Management.Semantic proximity Read ↗

Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathwaySemantic proximity Read ↗

Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategiesSemantic proximity Read ↗

Unraveling the Clinical Relevance of Ferroptosis-Related Genes in Human Ovarian AgingSemantic proximity Read ↗

The emerging role of ferroptosis in female reproductive disordersSemantic proximity Read ↗

Control of mitochondrial integrity influences oocyte quality during reproductive agingSemantic proximity Read ↗

Fisetin Delays Postovulatory Oocyte Aging by Regulating Oxidative Stress and Mitochondrial Function through Sirt1 PathwaySemantic proximity Read ↗

Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytesSemantic proximity Read ↗

Granulosa cell-specific FOXJ2 overexpression induces premature ovarian insufficiency by triggering apoptosis via mitochondrial calcium overloadSemantic proximity Read ↗

Ferroptosis: A Novel Type of Cell Death in Male ReproductionSemantic proximity Read ↗

C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.