Article

Extended Adverse Effects of Cyclophosphamide on Mouse Ovarian Function

2020-12-30

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose:</bold> Most patients with cancer undergo multiple administrations of anticancer drugs during treatment, resulting in chronic impairment of their reproductive health. As improved treatment options increase cancer survival, it has become increasingly important to address fertility issues in cancer survivors. In this study, we examined the pathophysiological effects of multi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 458bf0b1-5371-5078-a434-34dec76de63e
DOI: 10.21203/rs.3.rs-59493/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Extended Adverse Effects of Cyclophosphamide on Mouse Ovarian FunctionDOI 10.21203/rs.3.rs-59493/v3Read

Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transcription During Oocyte GrowthSemantic proximity Read

Cyclophosphamide chemotherapy induces early p53-directed cytotoxic gene expression changes in ovarian gonadotoxicitySemantic proximity Read

The mechanisms of cyclophosphamide-induced testicular toxicity and the protective agentsSemantic proximity Read

Novel insights into the pathophysiology of chemotherapy-induced damage to the ovarySemantic proximity Read

Cytotoxic Properties of Cyclophosphamide: A Focus on Its Mechanistic Impacts on Male Gonadal FunctionsSemantic proximity Read

MicroRNA profiling and identification of let-7a as a target to prevent chemotherapy-induced primordial follicles apoptosis in mouse ovariesSemantic proximity Read

The cyto-protective effects of LH on ovarian reserve and female fertility during exposure to gonadotoxic alkylating agents in an adult mouse modelSemantic proximity Read

<i>In Vivo</i> Mechanisms of Chemotherapy-Induced Acute Follicle Loss in the Human Ovary: An Individual-Oocyte Transcriptomic Analysis from Human Ovarian XenograftsSemantic proximity Read

Fertility recovery after combined adriamycin, bleomycin, vinblastine and dacarbazine chemotherapy in miceSemantic proximity Read

Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activationSemantic proximity Read

Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytesSemantic proximity Read

Identification of abnormal protein expressions associated with mouse spermatogenesis induced by cyclophosphamideSemantic proximity Read