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Thioredoxin-1 inhibits granulosa cell ferroptosis to rescue ovarian aging through mitophagy-dependent activation of BNIP3L

2025-07-14

Abstract excerpt

Ovarian aging is closely associated with a decline in fertility and an increase in reproductive dysfunction. Ovarian granulosa cells (GCs) support oocyte homeostasis and development, yet insight into GC dysfunction during aging is limited. Here, we show that aged GCs of humans and mice have indications of elevated ferroptosis, including increased ferroptosis-related metabolites, lipid peroxidation, and iron accumu...

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Identifiers and source

Literature Corpus work
7832d1f0-a882-55b4-a89d-380291e5173a
DOI
10.1101/2025.07.12.664497
Open publication

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