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Cell-free fat extract prevents diminished ovarian reserve by inhibiting granulosa cell senescence

29 May 2025

Abstract excerpt

BACKGROUND: Age-related diminished ovarian reserve (DOR) leads to declining fertility, miscarriage, and systemic health issues. Cell-free fat extract (CEFFE) has demonstrated therapeutic effects in various tissues. In our previous study, CEFFE successfully improved ovarian function in mice without adverse effects; however whether it can prevent DOR remains unclear. This study aimed to determine if early...

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PMID: 40442842
DOI: 10.1186/s13287-025-04383-6

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