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Mechanisms of Hydroxyurea‐Induced Cellular Senescence: An Oxidative Stress Connection?

1 Jan 2021

Abstract excerpt

Hydroxyurea (HU) is a water-soluble antiproliferative agent used for decades in neoplastic and nonneoplastic conditions. HU is considered an essential medicine because of its cytoreduction functions. HU is an antimetabolite that inhibits ribonucleotide reductase, which causes a depletion of the deoxyribonucleotide pool and dramatically reduces cell proliferation. The proliferation arrest, depending on drug...

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PMID: 34707779
DOI: 10.1155/2021/7753857

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