Article
Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1
2025-05-12
Abstract excerpt
<h4>Summary</h4> Human herpesviruses (HHVs) are widespread pathogens causing severe diseases, especially in immunocompromised individuals, and are linked to neurodegenerative and autoimmune disorders. Current antiviral therapies primarily target the α-subfamily, with limited options for β- and γ-subfamilies. The helicase-primase complex (HPC) is essential for viral DNA replication and represents a key antiviral t...
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Identifiers and source
- Literature Corpus work
- c1bb0a47-a487-54e1-8ebe-b9af9e1dd941
- DOI
- 10.1101/2025.05.12.653380