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Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity

2026-06-05

Abstract excerpt

Herpes simplex virus-1 (HSV-1) UL12 gene encodes a well-conserved 5’ → 3’ alkaline exonuclease. UL12 collaborates with the HSV single-strand DNA binding protein ICP8 to mediate recombination-dependent replication of viral DNA and is essential for the production of DNA that can be packaged into infectious virus. The UL12 gene has orthologs in the eight other human herpesviruses, including UL98 in HCMV and SOX in KS...

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Literature Corpus work
576f7070-2292-5dc7-8194-951aa33a7c96
DOI
10.64898/2026.06.03.729350
Open publication

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Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activityDOI 10.64898/2026.06.03.729350
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