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The three-component helicase/primase complex of herpes simplex virus-1

1 Jun 2021

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) is one of the nine herpesviruses that infect humans. HSV-1 encodes seven proteins to replicate its genome in the hijacked human cell. Among these are the herpes virus DNA helicase and primase that are essential components of its replication machinery. In the HSV-1 replisome, the helicase-primase complex is composed of three components including UL5 (helicase), UL52 (primase)...

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PMID: 34102080
DOI: 10.1098/rsob.210011

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