Article

Activating mGlu <sub>3</sub> metabotropic glutamate receptors rescues schizophrenia-like cognitive deficits through metaplastic adaptations within the hippocampus

2020-10-27

Abstract excerpt

<h4>Background</h4> Polymorphisms in GRM3 , the gene encoding the mGlu3 metabotropic glutamate receptor, are associated with impaired cognition and neuropsychiatric disorders such as schizophrenia. Limited availability of selective genetic and molecular tools has hindered progress in developing a clear understanding of the mechanisms through which mGlu3 receptors regulate synaptic plasticity and cognition. <h4>...

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Literature Corpus work: c1b2ac10-6c59-593c-81bd-4e10869d1dda
DOI: 10.1101/2020.10.27.356196

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