Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study.

Schizophrenia research - 1 Nov 2016

García-Bea Aintzane, Walker Mary A, Hyde Thomas M, Kleinman Joel E, Harrison Paul J, Lane Tracy A

Abstract excerpt

BACKGROUND: Metabotropic glutamate receptor 3 (mGlu3, mGluR3), encoded by GRM3, is a risk gene for schizophrenia and a therapeutic target. It is unclear whether expression of the receptor is altered in the disorder or related to GRM3 risk genotype. Antibodies used to date to assess mGlu3 in schizophrenia have not been well validated. OBJECTIVE: To characterise six commercially available anti-mGlu3 antibodies for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Brain Chemistry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Membrane

Share to HEK293 Cells

Share to Hydrogen-Ion Concentration

Share to Receptors, Metabotropic Glutamate

Share to Schizophrenia

Share to Temporal Lobe

Source

Open in PubMed Open full text

Identifiers

PMID: 27130562
DOI: 10.1016/j.schres.2016.04.015
PMCID: PMC5145804

Genes

GRM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study.PMID 27130562Read ↗

Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP.Semantic proximity Read ↗

No evidence for association between polymorphisms in GRM3 and schizophrenia.Semantic proximity Read ↗

Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein levels in schizophrenia.Semantic proximity Read ↗

Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune PathwaysSemantic proximity Read ↗

Activating mGlu <sub>3</sub> metabotropic glutamate receptors rescues schizophrenia-like cognitive deficits through metaplastic adaptations within the hippocampusSemantic proximity Read ↗

Further evidence for a functional role of the glutamate receptor gene GRM3 in schizophrenia.Semantic proximity Read ↗

Metabotropic glutamate receptor 3 is associated with heroin dependence but not depression or schizophrenia in a Chinese population.Semantic proximity Read ↗

Association between type-three metabotropic glutamate receptor gene (GRM3) variants and symptom presentation in treatment refractory schizophrenia.Semantic proximity Read ↗

Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patientsSemantic proximity Read ↗

Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.Semantic proximity Read ↗

DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study.Semantic proximity Read ↗

Genetic association, mutation screening, and functional analysis of a Kozak sequence variant in the metabotropic glutamate receptor 3 gene in bipolar disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.