Article

Cornichon Homolog-3 (Cnih3) deletion impairs spatial memory, reward-cue association, and fentanyl self-administration behavior

2025-11-13

Abstract excerpt

Opioid misuse remains rampant as new synthetic opioids reach the market. Large-scale genetic tools like the GWAS identify previously unrecognized targets and biomarkers in opioid misuse with hopes of combating the opioid epidemic. One such target is the AMPAR auxiliary protein Cornichon Homolog-3 (human analog: CNIH3, mouse analog: Cnih3), which determines AMPAR subunit composition and kinetics. Though CNIH3 was i...

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Literature Corpus work: f183f711-8564-5843-a619-1951fb15c178
DOI: 10.1101/2025.11.12.688051

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