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Article

Sex-dependent Schizophrenia and Drug Reward Behavioral Phenotypes in Metabotropic Glutamate 5 Receptor Heterozygous and Homozygous Mice.

Schizophrenia bulletin - 3 Jul 2026

Rosa Porto Rossana, Kreilaus Fabian, Hannan Anthony J, Chesworth Rose, Karl Tim

Abstract excerpt

BACKGROUND AND HYPOTHESIS: The metabotropic glutamate 5 (mGlu5) receptor is a potential therapeutic target for psychiatric disorders, including schizophrenia and substance use disorders. Indeed, mGlu5 is expressed in forebrain regions (eg, striatum, prefrontal cortex), and mGlu5 modulates N-methyl-D-aspartate receptor function and second messenger signaling. Also, male mice lacking mGlu5 display...

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Identifiers

PMID: 40981757
DOI: 10.1093/schbul/sbaf161
PMCID: PMC13391623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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