Article
The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia.
Scientific reports - 13 Oct 2016
Griebel Guy, Pichat Philippe, Boulay Denis, Naimoli Vanessa, Potestio Lisa, Featherstone Robert, Sahni Sukhveen, Defex Henry, Desvignes Christophe, Slowinski Franck, Vigé Xavier, Bergis Olivier E, Sher Rosy, Kosley Raymond, Kongsamut Sathapana, Black Mark D, Varty Geoffrey B
Abstract excerpt
Normalization of altered glutamate neurotransmission through activation of the mGluR2 has emerged as a new approach to treat schizophrenia. These studies describe a potent brain penetrant mGluR2 positive allosteric modulator (PAM), SAR218645. The compound behaves as a selective PAM of mGluR2 in recombinant and native receptor expression systems, increasing the affinity of glutamate at mGluR2 as inferred by...
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