Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling resilience to schizophrenia in genetically modified mice: a novel approach to drug discovery.

Expert review of neurotherapeutics - 1 Jul 2012

Mihali Andra, Subramani Shreya, Kaunitz Genevieve, Rayport Stephen, Gaisler-Salomon Inna

Abstract excerpt

Complex psychiatric disorders, such as schizophrenia, arise from a combination of genetic, developmental, environmental and social factors. These vulnerabilities can be mitigated by adaptive factors in each of these domains engendering resilience. Modeling resilience in mice using transgenic approaches offers a direct path to intervention, as resilience mutations point directly to therapeutic targets. As...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Adaptation, Psychological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Drug Discovery

Share to Gene-Environment Interaction

Share to Schizophrenia

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 22853787
DOI: 10.1586/ern.12.60
PMCID: PMC3509194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling resilience to schizophrenia in genetically modified mice: a novel approach to drug discovery.PMID 22853787Read ↗

Genetic mouse models of schizophrenia: from hypothesis-based to susceptibility gene-based models.Semantic proximity Read ↗

A polygenic resilience score moderates the genetic risk for schizophrenia.Semantic proximity Read ↗

"Targeting" schizophrenia in mice.Semantic proximity Read ↗

Genetic mouse models relevant to schizophrenia: taking stock and looking forward.Semantic proximity Read ↗

Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia.Semantic proximity Read ↗

Restoring wild type-like network dynamics and behaviour during adulthood in a mouse model of schizophreniaSemantic proximity Read ↗

Modeling madness in mice: one piece at a time.Semantic proximity Read ↗

Advancing a functional genomics for schizophrenia: psychopathological and cognitive phenotypes in mutants with gene disruption.Semantic proximity Read ↗

Mice with genetically altered glutamate receptors as models of schizophrenia: a comprehensive review.Semantic proximity Read ↗

Polygenic Resilience Scores are Associated with Lower Penetrance of Schizophrenia Risk Genes, Protection Against Psychiatric and Medical Disorders, and Enhanced Mental Well-Being and CognitionSemantic proximity Read ↗

Closing the translational gap between mutant mouse models and the clinical reality of psychotic illness.Semantic proximity Read ↗

Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.