Article

The Heart has Intrinsic Ketogenic Capacity that is Facultatively Upregulated in Heart Failure with Preserved Ejection Fraction

2021-06-22

Abstract excerpt

<title>Abstract</title> <p>Heart Failure with preserved Ejection Fraction or ‘HFpEF’ is now the most common type of heart failure worldwide, with considerable morbidity and mortality, and with no effective pharmacotherapies. For the first time, we show that the human and murine HFpEF heart have impaired uptake of ketone bodies, and reveal an intrinsic capacity of human and murine hearts to generate their own keto...

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Literature Corpus work: c19841b5-e0c6-5087-a626-d1f0e6b1a41e
DOI: 10.21203/rs.3.rs-607376/v1

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