Back to search

Article

A NRF2/β3-adrenoreceptor axis drives a sustained antioxidant and metabolic rewiring through the pentose-phosphate pathway to alleviate cardiac stress

2023-11-14

Abstract excerpt

<h4>Background</h4> Cardiac β3-adrenergic receptors (β3AR) are upregulated in diseased hearts and mediate antithetic effects to those of β1AR and β2AR. β3AR agonists were recently shown to protect from myocardial remodeling in preclinical studies and to improve systolic function in patients with severe heart failure. The underlying mechanisms, however, remain elusive. <h4>Methods</h4> To dissect functional, tran...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
46fdd928-0ba7-52a2-9890-fe5a4c836055
DOI
10.1101/2023.11.10.564735
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A NRF2/β3-adrenoreceptor axis drives a sustained antioxidant and metabolic rewiring through the pentose-phosphate pathway to alleviate cardiac stressDOI 10.1101/2023.11.10.564735
NRF2 activation in the heart induces glucose metabolic reprogramming and mediates cardioprotection via upregulation of the pentose phosphate pathwaySemantic proximity
CD163⁺/Dab2⁺ Macrophages Alleviate Cardiac Hypertrophy via Nrg2/ErbB4-Mediated Mitochondrial ReprogrammingSemantic proximity
Exercise-Induced Epoxy-Eicosanoids Promote Cardiomyocyte Proliferation and Post-Infarction Repair via NR4A1Semantic proximity
Early Transcriptomic Signatures of Reductive Stress Cardiomyopathy Reveal Insufficient HIF-1α SignalingSemantic proximity
Understanding Key Mechanisms of Exercise-Induced Cardiac Protection to Mitigate Disease: Current Knowledge and Emerging ConceptsSemantic proximity
A cocktail of B vitamins with nicotinamide riboside, folate and cobalamin preserves cardiac function and mitochondrial oxidative capacities in a mouse model of heart failureSemantic proximity
Transcriptome Data Analysis of Primary Cardiomyopathies Reveals Perturbations in Arachidonic Acid MetabolismSemantic proximity
Interferon gamma signaling drives cardiac metabolic rewiringSemantic proximity
Reciprocal Transcriptional Regulation of Metabolic and Signaling Pathways Correlates With Disease Severity in Heart FailureSemantic proximity
The dual PPAR-α/δ agonist elafibranor attenuates TGF-β <sub>1</sub> -induced cardiac fibrosis through redox-metabolic and bioenergetic reprogramming in human cardiac modelsSemantic proximity
β <sub>2</sub> -Adrenergic Signaling Switches from Cardioprotective to Cardiotoxic in Acute vs. Chronic Oxidative StressSemantic proximity
Metabolic reprogramming via PPARα signaling in cardiac hypertrophy and failure: From metabolomics to epigeneticsSemantic proximity
Select a neighboring publication to make it the new centre.