Article

IgG3 Hinge Architecture Expands Dengue Virus Breadth of A Quaternary Epitope Dependent Zika Virus Cross-Neutralizing Antibody

2026-03-19

Abstract excerpt

<h4>ABSTRACT</h4> Defining how antibodies achieve broad neutralization across antigenically related flaviviruses is essential for rational therapeutics and vaccine design. Here, we describe 3A06, a human monoclonal antibody that neutralizes dengue virus (DENV) serotypes 1-3 and zika virus (ZIKV). Notably, subclass switching to IgG3 exhibits expanded neutralizing activity against all four DENV serotypes. High-reso...

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Literature Corpus work: ca8df1ef-6e68-5a96-a2e2-02378bde9b34
DOI: 10.64898/2026.03.17.712406

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