Article

Distinct mechanisms of antibody-mediated HCV neutralization revealed by nanobody-guided epitope mapping

2026-08-03

Abstract excerpt

Hepatitis C virus (HCV) remains a major global health challenge despite the availability of highly effective antiviral therapies, underscoring the need for a broadly protective vaccine. The envelope glycoprotein E2 is the principal target of neutralizing antibodies, yet the full repertoire of vulnerable epitopes and mechanisms of antibody-mediated neutralization remains incompletely understood. Here, we exploited...

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Literature Corpus work: 300412f4-0fd0-58da-b54a-f1b5a431f922
DOI: 10.64898/2026.08.01.742232

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