Article

scTWAS: A powerful statistical framework for single-cell transcriptome-wide association studies

2025-09-30

Abstract excerpt

<title>Abstract</title> <p>Transcriptome-wide association studies (TWAS) have successfully identified genes associated with complex traits and diseases, but most rely on bulk transcriptome data, overlooking cell-type-specific contexts. Population-scale single-cell RNA sequencing data now enable such analyses, but present unique challenges due to strong noises, technical variations, and high sparsity. Here, we pro...

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Literature Corpus work: b46e1c47-60b8-5de6-a9af-ff178c2a476f
DOI: 10.21203/rs.3.rs-6531106/v1

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